1: 1. Derek's Death 2. Lexie and Mark's Fatal Plane Crash 3. George's Tragic Accident

2: 4. Cristina and Burke's Heartbreaking Breakup 5. Callie's Devastating Car Accident 6. Bailey's Miscarriage

3: 7. Amelia's Overdose 8. Meredith's Near-Drowning 9. Izzie's Cancer Diagnosis

4: 10. Arizona's Leg Amputation 11. April's Traumatic Pregnancy Loss 12. Richard's Near-Fatal Electrocution

5: 13. Owen's Sister's Death 14. Alex's Heartbreaking Goodbye 15. Addison's Miscarriage

6: 16. Mark's Death 17. Teddy's Daughter's Death 18. Bailey's Heart Surgery Scare

7: 19. Meredith's Alzheimer's Diagnosis 20. Jackson's Father's Death 21. Arizona and Callie's Custody Battle

8: 22. April's Failed Marriage 23. Derek and Meredith's Breakup 24. Mark and Lexie's Tragic Love Story

9: 25. Alex's Departure 26. Bailey's Heart Attack 27. Amelia's Brain Tumor